CCL11,alsoknownasEotaxin,isasmallcytokinebelongingtotheCCchemokinefamily.ThefulllengthofCCL11is97aminoacids(aa)witha23aasignalpeptide,whichiscleavedtogeneratea74aamatureprotein.ThemolecularmassofCCL11isabout10kD,anditsgeneislocatedontheqarmofchromosome17.CCL11expressionhasbeenfoundinnormaltissuessuchassmoothmuscleandsmallintestine.Endothelialcells,smoothmusclecells,epithelialcells,alveolarmacrophages,andeosinophilsareknowntoproduceCCL11.MouseCCL11sharesa61%and96%aminoacidsequenceidentitytobothhumanandrat,respectively.CCL11isproducedwheninflammatorycytokines,suchasIL-5andTNF-a,stimulatelungendothelialcells,fibroblasts,andsmoothmusclecellsinresponsetoallergens.Asapotenteosinophilchemoattractant,viabindingtoitsmajorreceptor,CCR3,CCL11efficientlyinducestheaccumulationofeosinophils,whichisaresponseassociatedwithallergicinflammation.Therefore,atopicdermatitis,asthma,andparasiticinfectionsareafewoftheeosinophilicinflammatorydiseasesdirectlyrelatedtoCCL11.Inaddition,CCL11inducestheformationofbloodvesselsandotherangiogenicresponseswhichareaccompaniedbyinflammatoryinfiltrationandisalsoinvolvedinregulationoftumordevelopment.TheLEGENDMAX™MouseCCL11ELISAkitisaSandwichEnzyme-LinkedImmunosorbentAssay(ELISA)witha96-wellstripplatethatispre-coatedwitharatmonoclonalanti-mouseCCL11antibody.Thedetectionantibodyisabiotinylatedgoatpolyclonalanti-mouseCCL11antibody.ThiskitisspecificallydesignedfortheaccuratequantitationofmouseCCL11fromcellculturesupernatant,serum,plasma,andotherBIOLOGicalfluids.Thiskitisanalyticallyvalidatedwithready-to-usereagents.

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